Midgut and Appendix
Since goblet cell NETs occur almost exclusively in the appendix, the typical presentation is acute appendicitis, with symptoms such as abdominal pain and swelling, loss of appetite, nausea and vomiting, constipation or diarrhea, and/or fever. Other, less common signs can include bowel obstruction, GI bleeding, inﬂamed lymph nodes in the abdomen or iron deﬁciency anemia.‡
‡ The classiﬁcation of Goblet Cell Carcinoma (GCC) as a NET is controversial, due to the fact that this type of tumour shares cellular features of both a NET and an adenocarcinoma. It is recommended that GCC tumours be meticulously examined by a pathologist to determine the best course of treatment and prognosis.