Many factors influence the type of treatment that doctors recommend for managing NETs, the most important of which is the specific type of tumour that is involved. Treatment plans are designed with several considerations in mind: stage of the disease, grade of the tumour and the type of hormones (if any) that are secreted by the tumour.

Generally, the goals of treatment are to: eliminate the tumour or reduce its size; control the effects of hormones produced by the tumour; manage complications and symptoms caused by the disease itself or hormone secretion.